Vitamin B6 is a group of water-soluble compounds (vitamers) that functions as a coenzyme in many reactions involved in amino acid, carbohydrates and lipid metabolism as well as the production of antibodies and red blood cells.*
Pyridoxal 5′-phosphate (P-5’-P) is the metabolically active form of vitamin B6, and it is involved in over 100 enzymatic reactions, many of which are related to protein metabolism.*[1,2]
In addition to protein metabolism, vitamin B6 helps release glycogen from the liver and muscles, suggesting its utility in exercise performance.*
The versatile vitamin/coenzyme also has been shown to protect lipids and proteins against glycation reactions as well as aid homocysteine methylation, indicating its role in supporting cardiovascular health.*[4,5]
Pyridoxal 5′-phosphate (P-5’-P) helps maintain the balance of sodium and potassium, which regulates body fluids and promotes healthy functioning of the nervous and musculoskeletal systems.*
To top it off, vitamin B6 also affects cognitive function and mood, and it is required for the biosynthesis of critical neurotransmitters, including GABA, dopamine, noradrenaline, serotonin.*
- Da Silva VR, Russell KA, Gregory JF 3rd. Vitamin B6. In: Erdman JW Jr., Macdonald IA, Zeisel SH. Present Knowledge in Nutrition. 10th ed: Wiley-Blackwell; 2012:307-320.
- Eliot AC, Kirsch JF. Pyridoxal phosphate enzymes: mechanistic, structural, and evolutionary considerations. Annu Rev Biochem. 2004;73:383-415. doi: 10.1146/annurev.biochem.73.011303.074021. PMID: 15189147.
- Manore MM. Vitamin B6 and exercise. Int J Sport Nutr. 1994;4:89–103. doi: 10.1123/ijsn.4.2.89.
- Ubbink JB, Vermaak WJ, van der Merwe A, Becker PJ, Delport R, Potgieter HC. Vitamin requirements for the treatment of hyperhomocysteinemia in humans. J Nutr. 1994;124(10):1927-1933.
- Stach K, Stach W, Augoff K. Vitamin B6 in Health and Disease. Nutrients. 2021;13(9):3229. Published 2021 Sep 17. doi:10.3390/nu13093229
- Scott TM, Tucker KL. Low plasma vitamin B6 predicts cognitive decline and depression in at-risk individuals. FASEB Journal 2013;27:346.6.